President Xiomara Castro announced a 15-day curfew in Choloma between 9:00 pm and 4:00 am, effective immediately, and another in San Pedro Sula, effective July 4.
Heavily armed men opened fire on Saturday night in a billiards hall in a neighbourhood in the northern manufacturing city of Choloma, killing 13 people and seriously wounding another, police press person Edgardo Barahona told Reuters.
He added at least 11 other murders had taken place on Saturday in separate episodes across the northern Valle de Sula zone, including in the industrial city of San Pedro Sulay.
"Multiple operations, raids, captures and checkpoints are initiated," Castro said via Twitter.
There has been a partial state of emergency in parts of Honduras since December in a bid to confront violent gangs and turf wars.
Security Minister Gustavo Sanchez announced later on Sunday that the government would be sending a proposal to Congress to "classify members of a criminal structure, maras or gangs as terrorists" in the coming days.
The minister, speaking at a press conference, added that 1,000 additional police and military are being sent to the Sula Valley, where Choloma and San Pedro Sul are located.
The government is also offering a cash reward of 800,000 Lempiras ($32,707) to help identify and capture those responsible for the killings in Choloma, the president said.
The attacks over the weekend follow a deadly incident earlier this week at a women's prison near the capital Tegucigalpa that killed 46 people amid a reported break-in by gang members.