Arsenal edged Napoli 1-0 to advance to the Europa League semi-finals 3-0 on aggregate.
Alexandre Lacazette scored a stunning 36th-minute free-kick to help the English club book a final-four meeting with Valencia, who were 5-1 aggregate winners over fellow Spaniards Villarreal.
Napoli’s exit means no Italian clubs are left in European competition this season.
Elsewhere, Chelsea registered a 4-3 win at home against Slavia Prague that saw them progress 5-3 after two legs.
The London side will face Eintracht Frankfurt for a place in the final after the German club beat Benfica 2-0 to go through on away goals after the tie ended 4-4 on aggregate.