Northern Ireland defender Jonny Evans will be sidelined for the "next few weeks" due to a thigh strain he suffered in the first half of United's 4-3 Champions League defeat at FC Copenhagen.
Manchester United said late on Friday.
He joins a lengthy injury list at United, who remain without defenders Lisandro Martinez, Luke Shaw, Tyrell Malacia and midfielder Casemiro.
The 35-year-old will miss Northern Ireland's final Euro 2024 qualifiers against Finland and Denmark. Northern Ireland, who sit fifth in Group H with six points, travel to Finland next Friday before hosting Denmark on November 20.
Evans rejoined United on a one-year deal in September, eight years after leaving Old Trafford and has started five league games.
United lie in eighth place in the top-flight after picking up 18 points in 11 matches and host promoted Luton Town later on Saturday.
Defending champion Jannik Sinner shattered home hopes Wednesday by crushing Alex de Minaur in a straight-sets rout to tee up an Australian Open semi-final against Ben Shelton.
Borussia Dortmund have fired coach Nuri Sahin, the German football club said on Wednesday, after Tuesday's shock 2-1 loss to Bologna in the Champions League that stretched their losing run to four games across all competitions.
A rampaging Iga Swiatek stormed into her second Australian Open semi-final with a 6-1 6-2 centre court demolition of eighth seed Emma Navarro on Wednesday, while Madison Keys overhauled Elina Svitolina 3-6 6-3 6-4 in the earlier quarter-final.
The MI Emirates produced a clinical display with the bat and the ball, handing the Abu Dhabi Knight Riders a 28-run defeat in the DP World ILT20 Season 3 at the Sheikh Zayed Stadium on Tuesday.
Liverpool booked their spot in the last 16 of the Champions League with a 2-1 victory over 10-man Lille on Tuesday at Anfield, thanks to goals from talisman Mohamed Salah and substitute Harvey Elliott.