Around one million people have fled the Gazan city of Rafah in the past three weeks, the United Nations Palestinian refugee agency (UNRWA) said on Tuesday.
The small city on the southern edge of the Gaza Strip had been sheltering more than a million Palestinians who fled Israeli assaults on other parts of the enclave.
Since early May, Israel's military has been carrying out what it says is a limited operation in Rafah to kill fighters and dismantle infrastructure used by Hamas. It has told civilians to go to an "expanded humanitarian zone" some 20 kilometres away.
Many Palestinians have complained they are vulnerable to Israeli attacks wherever they go and have been moving up and down the Gaza Strip in the past few months.
UNRWA said the flight from Rafah "happened with nowhere safe to go and amidst bombardments, lack of food and water, piles of waste and unsuitable living conditions."
Providing assistance and protection is becoming nearly "impossible", the agency said.
Hijackers being seated next to some of the scores of passengers taken hostage after insurgents took control of a train in southwest Pakistan, has complicating rescue efforts, security sources said on Wednesday.
The captain of a ship, who has been arrested in connection with a crash into a US flagged tanker off the coast of England is a Russian national, the German company which owns the vessel said on Wednesday.
A Russian missile attack on the central Ukrainian city of Kryvyi Rih killed a 47-year-old woman and wounded at least nine other people, Dnipropetrovsk regional governor Serhiy Lysak said on Wednesday.
Yemen's Houthis said on Tuesday they would resume attacks on Israeli ships passing through the Red and Arabian seas, the Bab al-Mandab Strait and the Gulf of Aden, ending a period of relative calm starting in January with the Gaza ceasefire.
US President Donald Trump's increased tariffs on all US steel and aluminum imports took effect on Wednesday, stepping up a campaign to reorder global trade norms in favour of the US that drew swift retaliation from Europe.