According to manager Ole Gunnar Solskjaer, the France midfielder needs an operation on his ankle.
The 26-year-old only made his comeback last month, as his ankle problem kept him out since late September last year.
Scott McTominay is currently also out injured.
Pogba has played only eight times this season after having surgery to correct another ankle injury.
Teenager Konstas to make debut in fourth test against India
Teenager Sam Konstas will make his test debut in the cauldron of the Boxing Day test at Melbourne Cricket Ground on Thursday as Australia look to take the game to India's bowlers, coach Andrew McDonald said on Tuesday.
Top football stars set for Dubai International Sports Conference
A flurry of current and former football stars are set to descend on Atlantis, The Palm on Friday evening for the 19th edition of the Dubai International Sports Conference and the Beyond Globe Soccer Dubai Awards.
India to play Champions Trophy matches in UAE
India will play their Champions Trophy matches in the UAE next year after hosts Pakistan selected the Gulf country as a neutral venue for their rivals, the Pakistan Cricket Board said.
Liverpool hit Tottenham for six to cement top spot, Chelsea held
Liverpool strengthened their hold on the Premier League top spot with an extraordinary 6-3 victory at battered Tottenham Hotspur after second-placed Chelsea were held to a frustrating 0-0 draw away to Everton on Sunday.
Juventus end stalemate run with 2-1 win at Monza
Juventus secured a 2-1 victory at bottom side Monza with first-half goals from Weston McKennie and Nicolas Gonzalez on Sundayto end a run of four Serie A draws.
